Determination of neutral alpha-glucosidase
EpiScreen Plus™ determines the activity of neutral alpha-glucosidase in semen (plasma), an enzyme secreted mainly by the epididymis. The activity of this enzyme is a reliable marker of epididymal function in patients with (very) low sperm concentration or in azoospermic patients, with normal blood androgen levels :
- very low activity indicates bilateral obstruction between the epididymis and the ejaculatory duct.
- low activity may reflect partial obstruction of the epididymis.
- normal enzyme activity is expected when there is an obstruction above the area in which the enzyme is secreted, or in cases of non-obstructive azoospermia (testicular dysfunction).
EpiScreen Plus™ is a semi-quantitative, non-automated, photometric, diagnostic kit for the detection of neutral alpha-glucosidase in human semen or seminal plasma and may be useful for the diagnosis and management of male infertility.
EpiScreen Plus has a shelf life of 24 months from the date of production. Information on product composition is available in the safety data sheet.